Introduction

If you’re taking Zepbound for weight loss and wondering whether it affects your ability to get pregnant—you’re not alone. Many women of reproductive age are prescribed Zepbound, especially those with PCOS, irregular cycles, or insulin resistance.

So can you still get pregnant while on Zepbound? Should you take it while trying to conceive? And what if you find out you’re already pregnant?

This blog answers those questions and breaks down everything you need to know about Zepbound and fertility.

Can You Get Pregnant While Taking Zepbound?

Yes—you absolutely can.

Zepbound does not prevent pregnancy, and many women actually become more fertile while using it due to:

• Improved insulin sensitivity

• Reduced inflammation

• Weight loss (which improves ovulation and hormone balance)

• Stabilized blood sugar and leptin levels

Several women with PCOS have reported getting pregnant after months (or years) of cycle irregularity, once they started Zepbound.

Is It Safe to Use Zepbound While Pregnant?

No.

Zepbound is not approved for use during pregnancy, and animal studies have shown potential risks to fetal development.

If you become pregnant while on Zepbound:

• Stop taking it immediately

• Call your doctor or OB-GYN

• You may be monitored with labs and ultrasounds to ensure fetal health

FDA guidance recommends stopping Zepbound at least 1 month before trying to conceive.

Should You Take Zepbound While Trying to Get Pregnant?

This is where it gets more personalized. You may consider Zepbound if:

You’re trying to lose weight before pregnancy
You have PCOS or insulin resistance
Your provider recommends it as part of a pre-conception plan

But:

You should stop Zepbound at least 4 weeks before actively trying to conceive, and definitely as soon as pregnancy is confirmed.

Always coordinate with your OB-GYN, endocrinologist, or fertility specialist.

How Zepbound May Improve Fertility (Especially with PCOS)

Issue	Zepbound’s Effect
Irregular periods	Weight loss + insulin control can regulate cycles
Insulin resistance	Improves glucose metabolism and ovulation
High androgens	Weight loss may reduce testosterone
Inflammation	GIP/GLP-1 activity may lower systemic inflammation

Related: Zepbound for PCOS – What You Need to Know

Birth Control Reminder

Because Zepbound can improve fertility, it’s important to use reliable birth control if you’re sexually active and not trying to get pregnant.

Pill, patch, IUD, or implant
Condoms or dual methods
Track your cycles more closely—some women ovulate earlier than expected as their health improves

Can Zepbound Help After Pregnancy?

Many women plan to return to Zepbound postpartum (with doctor approval), especially if:

• They gained significant weight during pregnancy

• Have persistent insulin resistance or Type 2 diabetes

• Want to lose weight safely after weaning

Zepbound is not approved for use while breastfeeding.

Final Thoughts

Zepbound does not prevent pregnancy—and in many women, it may improve fertility. However, it should not be used during pregnancy or while actively trying to conceive. Work with your provider to develop a safe timeline for treatment, ovulation, and stopping medication when appropriate.

Weight loss and metabolic improvements can support fertility
Stop Zepbound if pregnant or TTC
Use birth control unless you’re planning to conceive soon

Visit  Zepbound + Fertility Planning  to help you coordinate your goals with your healthcare team.