Introduction

Starting Zepbound can bring exciting changes—like reduced appetite and fast weight loss—but one not-so-welcome change for many users is constipation. If you’ve noticed slower digestion or discomfort since beginning treatment, you’re not alone.

In this guide, we’ll break down why Zepbound can cause constipation, how long it lasts, and the best strategies to keep your digestion moving smoothly.

Why Does Zepbound Cause Constipation?

Zepbound (tirzepatide) slows digestion by activating GLP-1 and GIP receptors, which:

• Reduce appetite

• Delay gastric emptying

• Help control blood sugar

This “slowing down” can also affect your gut motility—leading to:

• Less frequent bowel movements

• Harder stools

• Bloating or straining

Constipation is one of the most common early side effects, especially in the first 4–6 weeks or after a dose increase.

How Common Is It?

In clinical trials, up to 23% of Zepbound users reported constipation.

You’re more likely to experience it if:

• You’ve recently increased your dose

• You’re not drinking enough fluids

• You’re eating very little due to appetite loss

• You’re on a low-fiber diet

Signs of Zepbound-Related Constipation

Going fewer than 3 times per week
Straining or discomfort
Feeling of incomplete emptying
Bloating or gas
Hard, dry stools

How to Prevent or Relieve Constipation on Zepbound

1. Hydrate Aggressively

• Aim for 80–100 oz of water daily

• Include electrolytes if you feel fatigued or dehydrated

2. Eat More Fiber

• Focus on soluble + insoluble fiber from:
  • Berries, chia seeds, lentils, leafy greens, oats, flaxseed

• Consider a fiber supplement like psyllium husk or Benefiber

3. Keep Moving

• Even light exercise (e.g., walking 20–30 min/day) helps stimulate the colon

4. Add Magnesium

• Magnesium citrate or oxide may help promote bowel movements

• Start low to avoid diarrhea

5. Try a Natural Laxative (if needed)

• Options: prune juice, senna tea, Miralax (polyethylene glycol)

• Use occasionally—not daily—to avoid dependence

Sample “Zepbound Gut-Friendly” Day

Morning

• 1 glass warm lemon water

• Oatmeal with chia seeds + berries

• Coffee (if tolerated)

Lunch

• Grilled chicken wrap with spinach + hummus

• Side of cucumber + apple slices

Dinner

• Salmon, roasted broccoli, quinoa

• Glass of water with electrolytes

Snack

• Greek yogurt with flaxseed or psyllium

Related: Zepbound Meal Plan – What to Eat for Best Results

When to Call Your Doctor

Contact your provider if you experience:

• No bowel movement for 5+ days

• Severe pain, nausea, or bloating

• Blood in your stool

• No relief from over-the-counter remedies

Final Thoughts

Constipation is a common but manageable side effect of Zepbound. With enough hydration, fiber, and movement, most users find relief within a few weeks—and their digestive system adapts over time.

Increase water and fiber intake
Move your body daily
Use supplements or laxatives as a backup (not a crutch)
Don’t wait too long to address symptoms

More info: Zepbound Digestive Health  with hydration goals, fiber trackers, and GI symptoms.