Mounjaro: Uses, Side Effects, Cost & How to Save
Introduction
Mounjaro (tirzepatide) is an injectable medication developed by Eli Lilly and approved for the treatment of Type 2 diabetes. It is also gaining widespread attention for its off-label use in weight loss, with many providers prescribing it due to its unmatched results in clinical trials. While not yet FDA-approved for obesity, it is already being considered a major player in the weight loss medication landscape.
How Mounjaro Works
Mounjaro is the first medication to activate both GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptors. Together, these hormones help regulate blood sugar levels and appetite.
Key mechanisms include:
- Enhancing insulin production
- Slowing gastric emptying
- Suppressing appetite
- Supporting long-term weight reduction
FDA Approval & Off-Label Use
Use | Approval Status |
Type 2 Diabetes | ✅ FDA Approved |
Weight Loss | ⚠️ Off-label (Pending approval) |
Mounjaro for Weight Loss: Clinical Evidence
In the SURPASS-2 trial, Mounjaro outperformed Ozempic in both glucose control and weight reduction:
- Up to 22.5% average body weight loss in participants on the highest dose
- Significant improvement in A1C levels and metabolic health
📚 Source: New England Journal of Medicine – SURPASS-2 Study
Common Side Effects
Common | Less Common / Serious |
Nausea | Pancreatitis |
Diarrhea | Gallstones or cholecystitis |
Constipation | Hypoglycemia (especially with insulin) |
Fatigue | Possible thyroid tumor risk (animal data) |
Patients with a personal or family history of medullary thyroid carcinoma (MTC) or MEN 2 should not take Mounjaro.
Cost Comparison: U.S. vs Canada
Pharmacy | Price (Monthly) |
U.S. Retail | $1,000+ |
Canadian Pharmacy | $159 |
Through WeReviveRx | $450 |
💡 Ordering from a licensed Canadian pharmacy can cut costs by more than 50%.
Ways to Save on Mounjaro
- Lilly Mounjaro Savings Card
- As little as $25/month for eligible, commercially insured patients
- Not valid for Medicare/Medicaid patients
- GoodRx
- Discount coupons may be available in some locations
- WeReviveRx & Licensed Canadian Pharmacies
- Legal personal-use importation of a 90-day supply
- See the FDA’s Drug Importation Policy
Frequently Asked Questions
Can I take Mounjaro if I don’t have diabetes?
Yes. Many doctors prescribe it off-label for individuals with obesity or insulin resistance.
How fast does it work?
Appetite reduction often begins within 1–2 weeks. Noticeable weight loss may take 8–12 weeks.
Will insurance cover it for weight loss?
Usually not. Most plans cover Mounjaro only for Type 2 diabetes.
What happens if I stop taking it?
Discontinuing may lead to weight regain, so lifestyle changes are important for long-term success.
Final Thoughts
Mounjaro is one of the most promising prescription medications available for weight loss—even without formal obesity approval. With appropriate clinical supervision and cost-saving options, it may be an ideal choice for those seeking significant and sustained results.
Ideal for:
- Patients with Type 2 diabetes
- Adults with obesity or metabolic disorders
- Those who haven’t had success with other medications
📌 To explore pricing and availability, visit our Mounjaro pricing page.