Introduction

Starting a prescription weight loss medication like Wegovy, Zepbound, Ozempic, or Saxenda is a big decision—and one that should be made with the right guidance and realistic expectations.

Before you begin, it’s essential to have a clear conversation with your healthcare provider. Asking the right questions will help you understand the medication, set appropriate goals, and stay safe throughout your treatment.

Here are the top questions to ask before starting any weight loss medication.

1. Am I a good candidate for this medication?

Ask your provider:

• Do I meet the BMI and health condition requirements?
• Would this medication be off-label or FDA-approved for me?
• Are there other conditions (like thyroid issues or pancreatitis risk) that make it unsafe?

Knowing if you truly qualify ensures the medication is used appropriately and can improve your insurance approval chances.

2. What are the expected results?

Get clear on:

• How much weight can I expect to lose?
• How soon will I see results?
• What happens if I stop taking the medication?

Wegovy and Zepbound users often lose 15–22% of their body weight over 6–12 months when combined with lifestyle changes.

3. What are the most common side effects—and how can I manage them?

Important follow-up questions:

• How likely is nausea or fatigue?
• What should I do if I experience side effects?
• When should I call your office about symptoms?

Starting at a low dose and slowly increasing (titrating) often reduces digestive side effects.

4. How long will I need to take this medication?

• Is this a short-term boost or a long-term plan?
• What’s your process for reassessing or tapering off?

Many patients take GLP-1s for 12+ months, with regular check-ins to evaluate effectiveness.

5. How does this medication work with my current health conditions or medications?

Ask:

• Will it interact with my diabetes meds, blood pressure drugs, or antidepressants?
• Can it be safely combined with my supplements or vitamins?

Full medication reconciliation is key before starting any prescription.

6. Will my insurance cover it—and what are my options if not?

Key questions:

• Can you help with a prior authorization?
• What if it’s denied—can we appeal?
• Are there cheaper alternatives (like Ozempic or Contrave)?

Also ask about:

• Wegovy Savings Card  
• Zepbound Savings Card 
• Saxenda Savings Card
  

7. What kind of support do I need alongside the medication?

Consider:

• Should I see a dietitian or weight loss coach?
• Do you recommend a specific nutrition or exercise plan?
• Will I need regular lab work or progress check-ins?

Lifestyle changes are essential for long-term success—even with medication support.

8. What are the risks and when should I stop?

Understand:

• What signs would mean this medication isn’t right for me?
• How do we track safety long-term?

Be clear on red flags like severe abdominal pain, vomiting, or signs of thyroid issues.

Final Thoughts

Asking these questions ensures you’re informed, prepared, and supported before starting your weight loss medication. The right medication can be a powerful tool—but success depends on realistic expectations, open communication, and a strong partnership with your provider.

Don’t be afraid to advocate for yourself
Ask about cost, coverage, and support
Know how to monitor your progress and stay safe

For downloadable question checklists and insurance tips, visit our Weight Loss Medication Prep Hub.