Introduction

Prescription weight loss medications like Zepbound, Wegovy, Ozempic, and Saxenda are powerful tools—but they don’t come cheap. If you’re trying to decide which option fits your budget and goals, this cost comparison guide breaks it all down.

We’ll look at U.S. retail prices, Canadian pharmacy savings, and discount card options—so you can make the most informed (and affordable) choice.

Quick Overview: Average Monthly Costs (U.S. Retail)

Medication	Retail Price (U.S.)	Canadian Price (Estimate)	With Savings Card
Zepbound	~$1,060	~$450–$500	As low as $25
Wegovy	~$1,349	~$500–$600	As low as $0–$25
Ozempic	~$900–$1,200	~$419	As low as $25
Saxenda	~$1,200	~$515–$700	As low as $25
Mounjaro	~$1,060	~$450–$500	As low as $25 (if diabetic)

Learn more: How to Save on Zepbound – U.S. & Canada

Which Offers the Most Weight Loss Per Dollar?

Medication	Avg. Weight Loss	Price/Result Efficiency
Zepbound	Up to 22.5%	Highest weight loss per dollar spent
Wegovy	~15%	Great results, slightly higher cost
Ozempic	~10–15% (off-label)	Good option if covered for diabetes
Saxenda	5–8%	More frequent dosing = higher total cost
Mounjaro	Same as Zepbound	Equal, but not approved for weight loss

Zepbound is the most cost-effective choice for weight loss if you qualify for discounts or Canadian access.

Where to Get Discounts

Medication	Savings Program
Zepbound	Zepbound Savings Card
Wegovy	Wegovy Savings Offer
Ozempic	Ozempic Savings Card
Saxenda	Saxenda Savings Card
Mounjaro	Mounjaro Savings Program (diabetes only)

Savings cards usually apply to commercial insurance only (not Medicare/Medicaid/cash pay).

Canadian Pharmacy Prices

Buying from licensed Canadian pharmacies can reduce your monthly cost by 40–60%.

Medication	Est. Monthly Price (CAD → USD)
Zepbound	$450–$500
Wegovy	$500–$600
Ozempic	~$419
Saxenda	$515–$700
Mounjaro	~$450–$500

Legal in the U.S. to import a 90-day supply for personal use with a prescription.
Learn more: FDA Drug Importation Policy

Which Medication Is Most Likely to Be Covered by Insurance?

Medication	Coverage for Obesity	Notes
Zepbound	Growing rapidly	FDA-approved for weight loss
Wegovy	Most widely accepted	Strongest obesity coverage
Ozempic	Off-label only	Covered for diabetes, not obesity
Saxenda	Legacy option	Often covered by older formularies
Mounjaro	Only for diabetes	Not approved for weight loss

Learn more: Zepbound vs Ozempic – Off-Label vs On-Label Use

Final Thoughts

Choosing the right weight loss medication means weighing effectiveness, affordability, and coverage. Zepbound and Wegovy offer the most dramatic results, while Ozempic may be more accessible for those with diabetes. Canadian pharmacies and savings cards can make even premium options more affordable.

Zepbound = Best results-to-cost ratio (especially if uninsured)
Wegovy = Great if insurance covers it fully
Ozempic = Viable if you have diabetes + coverage
Saxenda = Option if newer meds aren’t covered
Mounjaro = Equal to Zepbound, but for diabetes only

For personalized recommendations, savings strategies, and side-by-side cost comparisons, visit our Weight Loss Medication Pricing Hub.