Introduction

Both Zepbound and Saxenda are FDA-approved GLP-1 medications for weight loss—but they differ in dosing, ingredients, and effectiveness.

If you’re deciding between a daily vs weekly injection—or just want the best results—this guide will walk you through everything you need to know to compare Zepbound vs Saxenda.

Quick Overview

Feature	Zepbound	Saxenda
Active Ingredient	Tirzepatide	Liraglutide
Hormones Targeted	GLP-1 + GIP	GLP-1 only
Dosing Frequency	Weekly injection	Daily injection
FDA Approval	2023 (weight loss)	2014 (weight loss)
Average Weight Loss	15–22.5% of body weight	5–8% of body weight

Both are approved for adults with BMI ≥30 or ≥27 with a weight-related condition.

Weight Loss Comparison

Medication	Avg. Weight Loss	Duration	Study
Zepbound	Up to 22.5%	72 weeks	SURMOUNT-1 Trial
Saxenda	5–8%	56 weeks	SCALE Trial

Zepbound produces 2–4x more weight loss on average than Saxenda.

How They Work

Zepbound (tirzepatide):

• Activates GLP-1 + GIP receptors
• Suppresses appetite, slows digestion
• Improves insulin response and metabolic health

Saxenda (liraglutide):

• Activates GLP-1 only
• Suppresses hunger and slows gastric emptying
• Taken once daily to maintain levels

GIP activation in Zepbound may enhance fat loss and reduce inflammation beyond what Saxenda can offer.

Dosing & Convenience

Feature	Zepbound	Saxenda
Frequency	Once per week	Once daily
Injection Type	Pre-filled pen	Pre-filled pen
Ease of Use	More convenient	Requires daily habit

Zepbound is more convenient for most patients due to weekly dosing.

Side Effects Comparison

Symptom	Zepbound	Saxenda
Nausea	Common (early on)	Common
Constipation	Sometimes	Sometimes
Injection fatigue	Weekly	Daily injections may be tedious

Both carry the same thyroid cancer warning (MTC/MEN-2) and are not for use in patients with these conditions.

Cost & Insurance

Medication	U.S. Price	Canadian Price	Savings Card	Coverage
Zepbound	~$1,060/mo	~$450–$500	Zepbound Savings	With PA
Saxenda	~$1,200/mo	~$500–$700	Saxenda Savings	Often

Both are FDA-approved for weight loss, but Zepbound may face more insurance hurdles due to being newer.

Who Should Consider Zepbound?

Great for those who:

• Want maximum fat loss
• Prefer weekly dosing
• Struggle with insulin resistance, PCOS, or metabolic issues
• Have failed on Saxenda or Wegovy

Who Should Consider Saxenda?

Great for those who:

• Don’t mind daily injections
• Want a medication with a longer safety track record
• May have insurance that won’t yet cover Zepbound
• Had success on Victoza (same ingredient)

Final Thoughts

Zepbound and Saxenda both offer FDA-approved weight loss treatment, but Zepbound delivers greater results with more convenience. Saxenda remains a strong alternative, especially for those who prefer a tried-and-true daily option.

Zepbound = stronger results, weekly dose, dual-action
Saxenda = steady daily dose, good for gradual goals
Choose based on lifestyle, insurance, and how your body responds

Visit our GLP-1 Comparison Guide to explore charts, savings links, and expert recommendations.